Investigating the mutational relationships in colorectal cancer
With Dr. Giorgio Melloni in the Park Lab, I am working to understand why some mutations co-occur at a frequency above that expected by chance alone using a pathway-level approach.
Tissue specificity of KRAS mutations
In collaboration with the Gygi (Dept. of Cell Bio., HMS) and Lauffenburger (MIT) Labs, we are searching for the reasons underpinning the results of KRAS mutations in different tissues. The question we are asking is, “Why are some KRAS mutations only oncogenic in a subset of tissues?” with the desire to better understand the mechanisms by which KRAS mutations induce oncogenesis.
Poulin et al., 2019
In the laboratory of Professor Melissa Lodoen, I investigated the patterns and mechanisms of dissemination by which Toxoplasma gondii, an obligate, intracellular parasite, infects a human host.
Cook et al., 2018